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Cite Details

Amy Bauer, Trachette Jackson and Yi Jiang, "A Cell-Based Model Exhibiting Branching and Anastomosis During Tumor-Induced Angiogenesis", Biophysical Journal , vol. 92, pp. 3105--3121, 2007

Abstract

This work describes the first cell-based model of tumor-induced angiogenesis. At the extracellular level, the model describes diffusion, uptake, and decay of tumor-secreted pro-angiogenic factor. At the cellular level, the model uses the cellular Potts model based on system-energy reduction to describe endothelial cell migration, growth, division, cellular adhesion, and the evolving structure of the stroma. Numerical simulations show: 1), different tumor-secreted pro-angiogenic factor gradient profiles dramatically affect capillary sprout morphology; 2), average sprout extension speeds depend on the proximity of the proliferating region to the sprout tip, and the coordination of cellular functions; and 3), inhomogeneities in the extravascular tissue lead to sprout branching and anastomosis, phenomena that emerge without any prescribed rules. This model provides a quantitative framework to test hypotheses on the biochemical and biomechanical mechanisms that control tumorinduced angiogenesis.

BibTeX Entry

@article{Bauer-angio-2007,
author = {Amy Bauer and Trachette Jackson and Yi Jiang},
title = {A Cell-Based Model Exhibiting Branching and Anastomosis During Tumor-Induced Angiogenesis},
year = {2007},
urlpdf = {http://math.lanl.gov/~yi/Papers/Bauer_Angio_BiophysJ_2007.pdf},
journal = { Biophysical Journal },
volume = {92},
pages = {3105--3121}
}