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Cite Details

Yilin Wu, Yi Jiang, Dale Kaiser and Mark Alber, "Type IV Pili Facilitate the Collective Motion of Bacteria: Modeling Myxobacterial Swarming", PLoS Computational Biology , vol. 3, pp. e253, 2007

Abstract

Swarming, a collective motion of many thousands of cells, produces colonies that rapidly spread over surfaces. In this paper we introduce a cell-based model to study how interactions between neighboring cells facilitate swarming. We chose to study Myxococcus xanthus, a species of myxobacteria, because it swarms rapidly and has welldefined cell-cell interactions, mediated by type IV pili and by slime trails. The aim of this paper is to test whether the cell contact interactions that are inherent in pili-based S motility and slime-based A motility are sufficient to explain the observed expansion of wild type swarms. The simulations yield a constant rate of swarm expansion, which has been observed experimentally. Also the model is able to quantify the contributions of S motility and A motility to swarming. Some pathogenic bacteria spread over infected tissue by swarming. The model described here may shed some light on the colonization process.

BibTeX Entry

@article{Wu-Swarm-2007,
author = {Yilin Wu and Yi Jiang and Dale Kaiser and Mark Alber},
title = {Type IV Pili Facilitate the Collective Motion of Bacteria: Modeling Myxobacterial Swarming},
year = {2007},
urlpdf = {http://math.lanl.gov/~yi/Papers/Wu_swarm_PLoS_2007.pdf},
journal = { PLoS Computational Biology },
volume = {3},
pages = {e253}
}