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Cite Details

Yi Jiang, Herbert Levine and James Glazier, " Differential adhesion and chemotaxis in mound formtaion of Dictyostelium", Biophys. J., vol. 75, pp. 2615, 1998


In the mound stage of Dictyostelium discoideum, pre-stalk cells sort and form a tip at the apex. The mechanisms by which this occurs is as yet unknown. A cellular level model allows us to simulate both differential cell adhesion and chemotaxis. Our simulations show that with differential adhesion only, pre-stalk cells move to the surface of the mound but form no tip. With chemotaxis to an outgoing circular wave only, a tip forms but contains both pre-stalk and pre-spore cells. Only for a narrow range of relative strengths between differential adhesion and chemotaxis, can both mechanisms work in concert to form a tip which contains only pre-stalk cells.

BibTeX Entry

author = {Yi Jiang and Herbert Levine and James Glazier},
title = { Differential adhesion and chemotaxis in mound formtaion of Dictyostelium},
year = {1998},
urlpdf = {http://math.lanl.gov/~yi/Papers/dicty.pdf},
journal = {Biophys. J.},
volume = {75},
pages = {2615}